Screening for Antinociceptive Action of Gastroretentive Drug delivery System of Tramadol hydrochloride in Mice

Abstract

The floating drug delivery system is to avoid the problem of drug waste and to limit the frequency of administration. Here the drug Tramadol is being centrally acting opioid analgesic can be formulated as sustained release formulation by adopting the method gastroretentive drug delivery system through effervescent floating drug delivery system with different grades of polymer Hyperomellose. The Pharmacological activity on Mice by both Hot Plate and Tail Flick Methods also suggest that when the Tramadol Hcl increased with its dosage form shows significant Analgesic Activity in animals which shows a spontaneous dose dependent increase in Analgesic activity was found it shows that the dosage form deserve for designed method of gastroretentive drug delivery system.